NAD+ broken down
Nicotinamide Adenine Dinucleotide (NAD) is a naturally occurring cofactor found in every cell within the body. The oxidised form of NAD, NAD+, is a precursor to potentially hundreds of metabolic functions within the body at a cellular level.
Researchers are exploring the form of NAD used in IV drip therapy.
A study carried out by Covarrubius in 2021 suggests NAD+ is central to energy metabolism, as well as properties such as DNA repair, healthy cellular ageing and metabolic homeostasis – simply put, the consistent balance of metabolic function within the body, for example energy production.
So, as well as being responsible for converting food to energy at a cellular level, this clever molecule ensures your cells function in the correct way and maintain the right balance to minimise the risk of cellular aging and disease.
Research is being done to discover the potential benefits for NAD+
The ‘science’ bit
Exploring the potential advantages of NAD+ in the body, studies have been examining the metabolic and age-related pathophysiology when NAD+ levels may be decreased, and what this means for your body.
Recent research into NAD+ carried out by Radenkovic in 2020 suggests the coenzyme could be a possible therapeutic treatment for age-related conditions such as chronic inflammation and immune decline.
Another study has been looking at combining NAD+ with booster vaccinations for treating viral illnesses.
While other research report improvement in blood pressure and liver health in elderly patients.
All NAD+ trials are currently within the early stages and show promise of possibly proving the benefits of supplementation.
Broken down, these are some of the ways in which NAD+ may aid and support the body:
- Neurological and cognitive function
- Muscle strength and function
- Energy levels
- The body’s aging process
NAD+ may aid and support the body’s aging process
NAD and anti-aging
Reportedly, as we age, our levels of NAD+ naturally deplete meaning the beneficial properties we see from are at risk of decreasing and DNA repair tails off meaning cells may be more susceptible to damage from external stressors.
Dr Johnny Parvanni, Founder and Chief Medical Officer of REVIV says: “There is a correlation between declining NAD+ levels and ageing as well certain diseased states which fuels curiosity for its role in health maintenance.”
An article printed in the Integrative Medicine journal in 2020, identifies that by the time we reach middle age, our NAD+ levels have plummeted to half of what they were in youth.
This is significant drop meaning many may not continue to experience the positive effects NAD+ can have on the body.
How to supplement NAD+
NAD+ can be supplemented orally or via an intravenous drip and due to science, we are now able to see more intravenous NAD therapies offered meaning a greater absorption rate.
This is because the coenzyme is delivered directly into the bloodstream, passing the filtration effect of the gut barrier.
Dr Parvanni says: “Due to the complex metabolism, it’s challenging to increase NAD+ levels where necessary through oral supplementation, with the intravenous (IV) route showing most efficacy.”
REVIV and NAD+ – the future of IV NAD+
REVIV were cautious in offering NAD+ to customers, Dr Parvanni explains: “The use of IV NAD+ for various therapeutic objectives has recently become more popular in alternative medicine.
“However, administration can be accompanied with various side effects and require additional safeguards. As such we, at REVIV, wanted more experience before offering this to our customers.
“After extensive internal review and pilot studies throughout our global network we have implemented the necessary policies to safely deliver NAD+ products to the highest regulatory standards, giving our customers a full range of product offerings available to the market.”
The new offering is available as a 250mg IV drip therapy and in four different packages. A single purchase, 1 Week Program with a delivery target on day 1 and 7, 2 Week Program with a delivery target on day 1, 7 and 14 and a 3 Week Program with a delivery target on day 1, 7, 14 and 21.
Treatments are subject to eligibility, availability, and consultation with a healthcare professional.
References
Covarrubius, A.J., Perrone, R., Grozio, A. and Verdin, E. (2021) ‘NAD+ metabolism and its roles in cellular processes during ageing’ In: Nat Rev Mol Cell Biol. 22 (2) pp 119-141
Mehmel, M., Jovanovic, N. and Spitz, U. (2020) ‘Nicotinamide Riboside- The Current State of Research and Therapeutic Uses’ In: Nutrients 12 (6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/
Rajman, L., Chwalek, K. And Sinclair, D.A. (2018) ‘Therapeutic potential of NAD-boosting molecules: the in vivo evidence’ in: Cell Metab. 27 (3) pp. 529–547
Shade, C. (2020) ‘The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule’ In: Integrative Medicine 19 (1) pp 12-14
Stocks, B., Ashcroft, S.P., Joanisse, S., Dansereau, L.C., Koay, Y.C., Elhassan, Y.S., Lavery, G.G., Quek, L., O’Sullivan, J.F., Philp, A.M, Wallis, G.A. And Philp, A. (2021) ‘Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise’ In: The Journal of Physiology 599 (5) pp. 1513-1531
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